JUNO, the receptor of sperm IZUMO1, is expressed by the human oocyte and is essential for human fertilisation
نویسندگان
چکیده
منابع مشابه
Cross-species fertilization: the hamster egg receptor, Juno, binds the human sperm ligand, Izumo1
Fertilization is the culminating event in sexual reproduction and requires the recognition and fusion of the haploid sperm and egg to form a new diploid organism. Specificity in these recognition events is one reason why sperm and eggs from different species are not normally compatible. One notable exception is the unusual ability of zona-free eggs from the Syrian golden hamster (Mesocricetus a...
متن کاملIzumo1 and Juno: the evolutionary origins and coevolution of essential sperm–egg binding partners
Reproductive proteins are among the most rapidly evolving classes of proteins. For a subset of these, rapid evolution is driven by positive Darwinian selection despite vital, well-conserved, reproductive functions. Izumo1 is the only essential sperm-egg fusion protein currently known on mammalian sperm, and its egg receptor (Juno; formerly Folr4) was recently discovered. Male knockout mice for ...
متن کاملstudy of cohesive devices in the textbook of english for the students of apsychology by rastegarpour
this study investigates the cohesive devices used in the textbook of english for the students of psychology. the research questions and hypotheses in the present study are based on what frequency and distribution of grammatical and lexical cohesive devices are. then, to answer the questions all grammatical and lexical cohesive devices in reading comprehension passages from 6 units of 21units th...
the present study is a survey os postmodern historical novel with respect to the voice of women. it argues how the recorded history is regulated by the rules of power and how women have been excluded from this discourse.ther study analysez angela carters nights at the circus as an example of postmodern historical novel to illustrate how this novel has questioned the historical narrative and how it has inserted women into history by breaking the rules of patriarchy.
the present thesis is a study of postmodern historical novel with respect to the voice of women. according to postmodern historiography,the established institution of history is one of the other manifestations of patriarchys power which has silenced women. the study analyzes angela carters nights at the circus as a postmodern historical novel which makes its female characters transgress the pat...
15 صفحه اولOocyte-triggered dimerization of sperm IZUMO1 promotes sperm–egg fusion in mice
Sperm-egg fusion is indispensable for completing mammalian fertilization. Although the underlying molecular mechanisms are poorly understood, requirement of two spermatozoon factors, IZUMO1 and SPACA6, and two oocyte factors, CD9 and the IZUMO1 counter-receptor JUNO, has been proven by gene disruption, and the binding of cells to an oocyte can be reconstituted by ectopic expression of IZUMO1. H...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Human Reproduction
سال: 2018
ISSN: 0268-1161,1460-2350
DOI: 10.1093/humrep/dey340